Irritable bowel syndrome

Irritable bowel syndrome

Irritable bowel syndrome (IBS) is a common disorder that affects the stomach and intestines, also called the gastrointestinal tract. Symptoms include cramping, abdominal pain, bloating, gas, diarrhea constipation, or both. IBS is a chronic condition that you'll need to manage long-term.

Only a small number of people with IBS have severe symptoms. Some people can control their symptoms by managing their diet, lifestyle, and stress. More severe symptoms can be treated with medication and counseling.

IBS doesn't cause changes in bowel tissue or increase your risk of colorectal cancer.

Symptoms of IBS

Symptoms of IBS vary but are usually present for a long time. The most common include:

·        Abdominal pain, cramping, or bloating that is related to passing a bowel movement

·        Changes in the appearance of bowel movement

·        Changes in how often you are having a bowel movement

Other symptoms that are often related include a sensation of incomplete evacuation and increased gas or mucus in the stool.

When to see a doctor

See your healthcare provider if you have a persistent change in bowel habits or other symptoms of IBS. They may indicate a more serious condition, such as colon cancer. More serious symptoms include:

·        Weight loss

·        Diarrhea at night

·        Rectal bleeding

·        Iron deficiency anemia

·        Unexplained vomiting

·        Pain that isn't relieved by passing gas or a bowel movement

Causes of IBS

The exact cause of IBS isn't known. Factors that appear to play a role include:

·        Muscle contractions in the intestine. The walls of the intestines are lined with layers of muscle that contract as they move food through your digestive tract. Contractions that are stronger and last longer than usual can cause gas, bloating, and diarrhea. Weak contractions can slow food passage and lead to hard, dry stools.

·        Nervous system. Issues with the nerves in your digestive system may cause discomfort when your abdomen stretches from gas or stool. Poorly coordinated signals between the brain and the intestines can cause your body to overreact to changes that typically occur in the digestive process. This can result in pain, diarrhea, or constipation.

·        Severe infection. IBS can develop after a severe bout of diarrhea caused by bacteria or a virus. This is called gastroenteritis. IBS might also be associated with a surplus of bacteria in the intestines (bacterial overgrowth).

·        Early life stress. People exposed to stressful events, especially in childhood, tend to have more symptoms of IBS.

·        Changes in gut microbes. Examples include changes in bacteria, fungi, and viruses, which typically reside in the intestines and play a key role in health. Research indicates that the microbes in people with IBS might differ from those in people who don't have IBS.

Triggers

Symptoms of IBS can be triggered by:

·        Food. The role of food allergy or intolerance in IBS isn't fully understood. A true food allergy rarely causes IBS. However many people have worse IBS symptoms when they eat or drink certain foods or beverages. These include wheat, dairy products, citrus fruits, beans, cabbage, milk, and carbonated drinks.

·        Stress. Most people with IBS experience worse or more frequent symptoms during periods of increased stress. But while stress may make symptoms worse, it doesn't cause them.

The Risk Factors of IBS

Many people have occasional symptoms of IBS. But you're more likely to have the syndrome if you:

• Are young. IBS occurs more frequently in people under age 50.
• Are female. In the United States, IBS is more common among women. Estrogen therapy before or after menopause also is a risk factor for IBS.
• Have a family history of IBS. Genes may play a role, as may shared factors in a family's environment or a combination of genes and environment.
• Have anxiety, depression, or other mental health issues. A history of sexual, physical, or emotional abuse also might be a risk factor.

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Complications of IBS

Chronic constipation or diarrhea can cause hemorrhoids.

In addition, IBS is associated with:

• Poor quality of life. Many people with moderate to severe IBS report poor quality of life. Research indicates that people with IBS miss three times as many days from work as those without bowel symptoms.
• Mood disorders. Experiencing the symptoms of IBS can lead to depression or anxiety. Depression and anxiety also can make IBS worse.

Diagnosis of IBS

There's no test to definitively diagnose IBS. Your healthcare provider is likely to start with a complete medical history, physical exam, and tests to rule out other conditions, such as celiac disease and inflammatory bowel disease (IBD).

After other conditions have been ruled out, your provider is likely to use one of these sets of diagnostic criteria for IBS:

• Rome criteria. These criteria include belly pain and discomfort averaging at least one day a week in the last three months. This must also occur with at least two of the following: Pain and discomfort related to defecation, a change in the frequency of defecation, or a change in stool consistency.
• Type of IBS. For the purpose of treatment, IBS can be divided into four types, based on your symptoms: constipation-predominant, diarrhea-predominant, mixed or unclassified.

Your provider will also likely assess whether you have other symptoms that might suggest another, more serious, condition. These include:

• Onset of symptoms after age 50
• Weight loss
• Rectal bleeding
• Fever
• Nausea or recurrent vomiting
• Belly pain, especially if it's not related to a bowel movement, or occurs at night
• Diarrhea that is ongoing or awakens you from sleep
• Anemia related to low iron

If you have these symptoms, or if an initial treatment for IBS doesn't work, you'll likely need additional tests.

Additional tests

Your provider may recommend several tests, including stool studies to check for infection. Stool studies also can check to see if your intestine has trouble taking in nutrients. This is a disorder known as malabsorption. Additional tests may be recommended to rule out other causes of your symptoms.

Diagnostic procedures can include:

• Colonoscopy. Your provider uses a small, flexible tube to examine the entire length of the colon.
• CT scan. This test produces images of your abdomen and pelvis that might rule out other causes of your symptoms, especially if you have belly pain.
• Upper endoscopy. A long, flexible tube is inserted down your throat and into the esophagus, which connects your mouth and stomach. A camera on the end of the tube allows your provider to view your upper digestive tract. During an endoscopy, a tissue sample (biopsy) may be collected. A sample of fluid may be collected to look for overgrowth of bacteria. An endoscopy may be recommended if celiac disease is suspected.

Laboratory tests can include:

• Lactose intolerance tests. Lactase is an enzyme you need to digest the sugar found in dairy products. If you don't produce lactase, you may have problems similar to those caused by IBS, including belly pain, gas, and diarrhea. Your provider may order a breath test or ask you to remove milk and milk products from your diet for several weeks.
• Breath test for bacterial overgrowth. A breath test also can determine if you have bacterial overgrowth in your small intestine. Bacterial overgrowth is more common among people who have had bowel surgery or who have diabetes or some other disease that slows down digestion.
• Stool tests. Your stool might be examined for bacteria, parasites, or the presence of bile acid. Bile acid is a digestive liquid produced in your liver.

Treatment of IBS

Treatment of IBS focuses on relieving symptoms so that you can live as symptom-free as possible.

Mild symptoms can often be controlled by managing stress and by making changes in your diet and lifestyle. Try to:

• Avoid foods that trigger your symptoms
• Eat high-fiber foods
• Drink plenty of fluids
• Exercise regularly
• Get enough sleep

Your provider might suggest that you eliminate from your diet:

• High-gas foods. If you experience bloating or gas, you might avoid carbonated and alcoholic beverages and certain foods that may lead to increased gas.
• Gluten. Research shows that some people with IBS report improvement in diarrhea symptoms if they stop eating gluten (wheat, barley, and rye) even if they don't have celiac disease.
• FODMAPs. Some people are sensitive to certain carbohydrates such as fructose, fructans, lactose, and others, known as FODMAPs — fermentable oligosaccharides, disaccharides, monosaccharides, and polyols. FODMAPs are found in certain grains, vegetables, fruits, and dairy products.

A dietitian can help you with these diet changes.

If your problems are moderate or severe, your provider might suggest counseling — especially if you have depression or if stress tends to make your symptoms worse.

Based on your symptoms, medications may be recommended, including:

• Fiber supplements. Taking a supplement such as psyllium (Metamucil) with fluids may help control constipation.
• Laxatives. If fiber doesn't help constipation, your provider may recommend over-the-counter laxatives, such as magnesium hydroxide oral (Phillips' Milk of Magnesia) or polyethylene glycol (Miralax).
• Anti-diarrheal medications. Over-the-counter medications, such as loperamide (Imodium A-D), can help control diarrhea. Your provider might also prescribe a bile acid binder, such as cholestyramine (Prevalite), colestipol (Colestid), or colesevelam (Welchol). Bile acid binders can cause bloating.
• Anticholinergic medications. Medications such as dicyclomine (Bentyl) can help relieve painful bowel spasms. They are sometimes prescribed for people who have bouts of diarrhea. These medications are generally safe but can cause constipation, dry mouth, and blurred vision.
• Tricyclic antidepressants. This type of medication can help relieve depression, but it also inhibits the activity of neurons that control the intestines. This may help reduce pain. If you have diarrhea and abdominal pain without depression, your provider may suggest a lower-than-typical dose of imipramine (Tofranil), desipramine (Norpramin), or nortriptyline (Pamelor). Side effects — which might be reduced if you take the medication at bedtime — can include drowsiness, blurred vision, dizziness, and dry mouth.
• SSRI antidepressants. Selective serotonin reuptake inhibitor (SSRI) antidepressants, such as fluoxetine (Prozac) or paroxetine (Paxil), may help if you are depressed and have pain and constipation.
• Pain medications. Pregabalin (Lyrica) or gabapentin (Neurontin) might ease severe pain or bloating.

Medications specifically for IBS

Medications approved for certain people with IBS include:

• Alosetron (Lotronex). Alosetron is designed to relax the colon and slow the movement of waste through the lower bowel. It can be prescribed only by providers enrolled in a special program. Alosetron is intended only for severe cases of diarrhea-predominant IBS in women who haven't responded to other treatments. It is not approved for use by men. Alosetron has been linked to rare but important side effects, so it should only be considered when other treatments aren't successful.
• Eluxadoline (Viberzi). Eluxadoline can ease diarrhea by reducing muscle contractions and fluid secretion in the intestine. It also helps increase muscle tone in the rectum. Side effects can include nausea, abdominal pain, and mild constipation. Eluxadoline has also been associated with pancreatitis, which can be serious and more common in certain individuals.
• Rifaximin (Xifaxan). This antibiotic can decrease bacterial overgrowth and diarrhea.
• Lubiprostone (Amitiza). Lubiprostone can increase fluid secretion in your small intestine to help with the passage of stool. It's approved for women who have IBS with constipation and is generally prescribed only for women with severe symptoms who haven't responded to other treatments.
• Linaclotide (Linzess). Linaclotide can also increase fluid secretion in your small intestine to help you pass stool. Linaclotide can cause diarrhea, but taking the medication 30 to 60 minutes before eating might help.

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